Literature Mining and Ontology based Analysis of Host-Brucella Gene–Gene Interaction Network

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Literature Mining and Ontology based Analysis of Host-Brucella Gene–Gene Interaction Network

Brucella is an intracellular bacterium that causes chronic brucellosis in humans and various mammals. The identification of host-Brucella interaction is crucial to understand host immunity against Brucella infection and Brucella pathogenesis against host immune responses. Most of the information about the inter-species interactions between host and Brucella genes is only available in the text o...

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Ontology-based representation and analysis of host-Brucella interactions

BACKGROUND Biomedical ontologies are representations of classes of entities in the biomedical domain and how these classes are related in computer- and human-interpretable formats. Ontologies support data standardization and exchange and provide a basis for computer-assisted automated reasoning. IDOBRU is an ontology in the domain of Brucella and brucellosis. Brucella is a Gram-negative intrace...

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Extension of the Interaction Network Ontology for Literature Mining of Gene-gene Interaction Networks from Sentences with Multiple Interaction Keywords

The Interaction Network Ontology (INO) has been demonstrated to be valuable in providing a structured ontological vocabulary for literature mining of gene-gene interactions from biomedical literature. Our analysis of the Learning Logic in Language (LLL) challenge and vaccine datasets showed that many interactions are signaled with 2 or more interaction keywords used in combination. In this pape...

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BACKGROUND Fever is one of the most common adverse events of vaccines. The detailed mechanisms of fever and vaccine-associated gene interaction networks are not fully understood. In the present study, we employed a genome-wide, Centrality and Ontology-based Network Discovery using Literature data (CONDL) approach to analyse the genes and gene interaction networks associated with fever or vaccin...

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ژورنال

عنوان ژورنال: Frontiers in Microbiology

سال: 2015

ISSN: 1664-302X

DOI: 10.3389/fmicb.2015.01386